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Dosage Form | |
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Strength | 1 mg/ml |
Pack Size | 4 mg vial |
Generic Names | |
Manufacturer |
Topotecan has the same mechanism of action as irinotecan and is believed to exert its cytotoxic effects during the S-phase of DNA synthesis. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. This ternary complex interferes with the moving replication fork, which leads to the induction of replication arrest and lethal double-stranded breaks in DNA. As mammalian cells cannot efficiently repair these double strand breaks, the formation of this ternary complex eventually leads to apoptosis (programmed cell death).
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Dosage Form | |
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Strength | 1 mg/ml |
Pack Size | 4 mg vial |
Generic Names | |
Manufacturer |
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