Covid-19 Info:
We keep delivering!
We have COVID-19 Safety Plan and are committed to keeping you safe.
Dosage Form | |
---|---|
Strength | 125 mg |
Generic Names | |
Manufacturer |
Treatment of breast cancer cell lines with the combination of palbociclib and antiestrogens leads to decreased retinoblastoma protein (Rb) phosphorylation resulting in reduced E2F expression and signaling and increased growth arrest compared to treatment with each drug alone. In vitro treatment of ER-positive breast cancer cell lines with the combination of palbociclib and antiestrogens leads to increased cell senescence, which was sustained for up to 6 days following drug removal. In vivo studies using a patient-derived ER-positive breast cancer xenograft model demonstrated that the combination of palbociclib and letrozole increased the inhibition of Rb phosphorylation, downstream signaling and tumor growth compared to each drug alone. Palbociclib is an oral, reversible, selective, small-molecule inhibitor of CDK4 and CDK6. CDK4 and CDK6 along with their regulatory partner cyclin D1 play a key role in regulating the G1- to S-phase cell-cycle transition via regulation of phosphorylation of the retinoblastoma (Rb) protein.
৳ 2,600.00
In stock
Dosage Form | |
---|---|
Strength | 125 mg |
Generic Names | |
Manufacturer |
Search from thousands of medicine and health products for your daily needs. Preskriptionpoint will ship them to your door with our fastest facility.
Accounts
Stop! This is a test environment, not a live site yet. please wait until the final publication for any order.
Something isn’t Clear?
Feel free to contact us, and we will be more than happy to answer all of your questions.
Covid-19:
We keep delivering!