Curcuminoids is the yellow pigment of Curcuma longa and has long traditional medicinal use in gastric ulcers and dyspepsia. Modern cellular studies on Curcuminoids with almost 4000 pre-clinical investigations, prove it as one of the best studied natural products of the whole biomedical literature. Curcuminoids is known as a master switch of addressing the natural inflammatory response function by down regulating the expression of a series of cytokines, enzymes and transcription factors. Curcuminoids significantly reduces the expression of COX-2, TNF-_, IL-1_, IL-1RN and IL-6. It inhibits the formation of prostaglandin. Curcuminoids also has anti oxidative, anti-tumoral, anti-microbial and choleretic action.