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Dosage Form | |
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Strength | 20 mg/ml |
Pack Size | 100 mg vial. |
Generic Names | |
Manufacturer |
Irinotecan inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex. The formation of this ternary complex interferes with the moving replication fork, which induces replication arrest and lethal double-stranded breaks in DNA. As a result, DNA damage is not efficiently repaired and apoptosis (programmed cell death) occurs.
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In stock
Dosage Form | |
---|---|
Strength | 20 mg/ml |
Pack Size | 100 mg vial. |
Generic Names | |
Manufacturer |
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